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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Escin, Sorafenib
Phytochemical Name Escin (PubChem CID: 16211024 )
Anticancer drug Name Sorafenib (PubChem CID: 216239 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Sorafenib
Adverse Reactions Facial red macules, dry skin, acne, alveolitis. This was inferred hot nature anticancer drug.
Recommendations Cold: Ilex hainanensis; Mangifera indica; Camellia sinensis; Sophora flavescens; Eriobotrya japonica; Citrus aurantium;
Reference Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022.　　ref_link
Combination Pair ID: 600
Ref_1
Pair Name Escin, Sorafenib
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation Down-regulation Expression ATG5 hsa9474
Up-regulation Expression MAP1LC3B hsa81631
Up-regulation Expression SQSTM1 hsa8878
In Vitro Model A-549 Lung adenocarcinoma Homo sapiens (Human) CVCL_0023
NCI-H460 Lung large cell carcinoma Homo sapiens (Human) CVCL_0459
In Vivo Model Wistar rats, aged between 6 and 8 weeks, weighing 150–200 g (male),were uesd in study.
Result This combination also selectively targeted G0/G1 phase of cancer cells. In in vivo study, the combination reduced tumour load and lower elevated serum biochemical parameters. The combination of sorafenib/escin synergistically inhibits autophagy to induce late apoptosis in lung cancer cells' G0/G1 phase.
Enhancing Drug Efficacy
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Combination Pair ID: 943
Ref_2
Pair Name Escin, Sorafenib
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation Up-regulation Expression BECN1 hsa8678
Up-regulation Expression MAP1LC3B hsa81631
Up-regulation Expression SQSTM1 hsa8878
In Vitro Model Hep-G2 Hepatoblastoma Homo sapiens (Human) CVCL_0027
In Vivo Model For the following 4 weeks, the animalsreceived daily treatments of water/saline as vehicle, sorafenib (10 mg/kgbw, oral) and escin (10 mg/kg bw, i.p.) alone and also in combination.
Result Escin and sorafenib combination potentially up-regulates p62 to block autophagy to induce late apoptosis in liver cancer cells.
03. Reference
No. Title Href
1 Escin enhanced the efficacy of sorafenib by autophagy-mediated apoptosis in lung cancer cells. Phytother Res. 2023 Oct;37(10):4819-4837. doi: 10.1002/ptr.7948. Click
2 Escin-sorafenib synergy up-regulates LC3-II and p62 to induce apoptosis in hepatocellular carcinoma cells. Environ Toxicol. 2024 Feb;39(2):840-856. doi: 10.1002/tox.23988. Click
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